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What is aspirin-exacerbated respiratory disease (AERD)?

How is AERD treated? Is there a cure?

There is no cure for AERD, but several treatment options are available, depending on symptoms and the results of a clinical evaluation. A combination of treatments often works best. Options include:

  • Avoiding aspirin and NSAIDs, unless your doctor specifically prescribes desensitization to aspirin
  • Taking medications to manage asthma, such as inhaled corticosteroids
  • Surgery to remove nasal polyps, though recurrence is common
  • Taking medication such as montelukast (Singulair) or zileuton (Zyflo) to block the effects of leukotrienes
  • Taking biologic medications, given by injection, for asthma or polyps when other medications don't work (although these drugs may be expensive)
  • Undergoing desensitization to aspirin, in which aspirin is initially given in the doctor's office in gradually increasing doses over two days and then taken daily at high doses, which may help reduce the need for oral steroids and possibly reduce the recurrence of nasal polyps